报 告 人：Qing Nie Departments of Developmental & Cell Biology and Mathematics NSF-Simons Center for Multiscale Cell Fate ResearchUniversity of California, Irvine
报告题目：Multiscale cell fate through lens of single cells
Cells make fate decisions in response to dynamic environmental and pathological stimuli as well as cell-to-cell communications. Recent technological breakthroughs have enabled to gather data in previously unthinkable quantities at single cell level, starting to suggest that cell fate decision is much more complex, dynamic, and stochastic than previously recognized. Multiscale interactions, sometimes through cell-cell communications, play a critical role in cell decision-making. Dissecting cellular dynamics emerging from molecular and genomic scale in single-cell demands novel computational tools and multiscale models. In this talk, through multiple biological examples we will present our recent works to use single-cell RNA-seq data and spatial imaging data to uncover new insights in development, regeneration, and cancers. We will also present several new computational tools and mathematical modeling methods that are required to study the complex and dynamic cell fate process through the lens of single cells.
Dr. Qing Nie is a Chancellor’s Professor of Mathematics, Developmental and Cell Biology, and Biomedical Engineering at University of California, Irvine. Dr. Nie is the director of the new NSF-Simons Center for Multiscale Cell Fate Research jointly funded by NSF and the Simons Foundation – one of the four national centers on mathematics of complex biological systems. In research, he uses systems biology and data-driven methods to study complex biological systems with focuses on single-cell analysis, multiscale modeling, cellular plasticity, stem cells, embryonic development, and their applications to diseases. Dr. Nie has published more than 140 research articles and served in many NIH and NSF review panels, maintaining a well-funded interdisciplinary research program. In training, Dr. Nie has supervised more than 40 postdoctoral fellows and PhD students, with majority of them working in academic institutions. Dr. Nie is a fellow of the America Association for the Advancement of Science and a fellow of American Physical Society.